Helen Bishop is a single mother of two children. In the early 1960s, she lived in Betty Francis's Ossining neighborhood, where she volunteered for John F. Kennedy’s presidential campaign. Her status as a divorcee as well as her habit of taking long walks made her the subject of local gossip. One evening while still married to Don Draper, Betty babysat Helen's son Glen and gave him a lock of hair. When Helen confronted Betty at the grocery store, Betty slapped her in the face.

Helen left Ossining for a while but has returned with her new husband. Helen’s ex-husband works in the insurance industry.