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Cullen Bohannon is a former Confederate soldier who served as head of the Union Pacific Railroad.
Elam Ferguson is an emancipated slave coming to terms with his newly-acquired freedom.
Thomas “Doc" Durant is a greedy entrepreneur taking full advantage of the changing times.
The Swede is a mysterious Norwegian immigrant whose fixation with Bohannon drove him to murder.
Louise Ellison is a strong-willed reporter for The New York Tribune, dispatched to Hell on Wheels.
Eva is a former Indian captive turned whore whose past constantly haunts her.
Mickey is the owner of a casino and whorehouse and the honorary Mayor of Cheyenne.
Ruth is a compassionate minister who creates an oasis in the debauched railroad town.
Psalms is the walking boss in Hell on Wheels, in addition to being de facto uncle to Elam's baby.
Cambell arrives in Cheyenne determined to civilize the West and seize control of the city.
The owner of the Palmer Ranch and the Palmer Hotel, Maggie is the richest woman in Cheyenne.
Ezra is an orphan and one of the only children in Cheyenne.
Naomi is a devout, strong-willed and beautiful Mormon girl, married to Cullen Bohannon.
Sean was an Irish immigrant who sought his fortune in the American west with his brother, Mickey.
Lily Bell was a young widow who tried making her own way in a world that had no place for her.
Joseph struggled between his Cheyenne Indian heritage and the changing world around him.
Reverend Cole wrestled with his own personal demons while preaching a path of peace.