There are darker forces guiding Vader (James Earl Jones) than ambition. Human traits like that were stamped out long ago. Hell, he'd kill his own children to control the universe. And don't bother running. He can choke you in thin air.

Industrialist Norman Osborn (Willem Defoe) trades in his pinstripe suit for body-armor when he's going Goblin. Besides being super-strong, he's a crack shot with a pumpkin bomb. Head for cover, especially if you're Spidey.